About the Action of Bupropion, or Amfebutamone (Wellbutrin, Zyban)

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Bupropion (Wellbutrin, Zyban), described at greater length on the Bupropion page, is a structurally novel anti-depressant.

Why is Bupropion Used?

Bupropion is a structurally novel anti-depressant prescribed to treat depression, generalized anxiety disorder, and social anxiety disorder (social phobia).

How Does Bupropion Work?

Bupropion acts as a relatively weak inhibitor of the neuronal uptake of norepinephrine (also called noradrenaline in the United Kingdom), serotonin, and dopamine, and it does not inhibit monoamine oxidase. Bupropion's action as an anti-depressant is thought to be related to its effects on the noradrenergic and/or dopaminergic systems within the brain. However, its full mechanism of action is not entirely understood.

Also see the page on Selective Serotonin Reuptake Inhibitors.

This page was last reviewed by Dr Greg Mulhauser, Tuesday, 22 April 2008.

The URL of this page is:
http://counsellingresource.com/medications/medication-types/novel-wellbutrin.html