Skelaxin (metaxalone) is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified.
Medications Commonly Used as Analgesics or Muscle Relaxants, Page 3

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Analgesics and muscle relaxants are used in the treatment of a wide range of chronic pain conditions which have a high rate of comorbidity with common mental health complaints, including depression and anxiety.
